GradyVet PAL Lasers

HOW DOES IT WORK? The effects of all light and laser therapies are primarily photochemical; not thermal – at least, not on a macro-scale – and result from a chain of mechanisms initiated by photon absorption:

• Primary: Absorption of photons by photo-receptive molecules (e.g. cytochromes, porphyrins, etc.) and the transduction of photon energy to induce chemical changes (i.e., photochemistry)
• Secondary: Modulation of ATP production (dose dependent), Nitric Oxide release, and the formation of Reactive Oxygen Species (ROS);
• Tertiary: The products of secondary mechanisms then produce effects such as gene transcription, inter-cellular signaling, and vasodilation; and,
• Quaternary: Vasodilation increases perfusion, facilitating improved oxygenation and recruitment of macrophages, neutrophils and lymphocytes to areas undergoing repair and/or infection as well as further re-vascularization and proliferation of cells to aid healing. Improved perfusion will also facilitate clearance of inflammatory cells, fluids and debris (i.e. lymphatic drainage) more efficiently.

The bulk of the research to date has been conducted with lasers emitting one watt or less per laser diode – this has been the gold standard and has been proven both safe and effective. At this point, there is not a single peer reviewed article that shows that lasers that exceed one watt to be more effective. In Confounders and Magicians, laser experts Jan Tuner and Lars Hode state the following: ” A certain power is of course necessary, but too much costs just more money and does not give better results…it is easy to make strong laser (we regard lasers with output power exceeding 1 watt as unnecessary strong” To learn more, please explore the independent articles and research below: Mechanisms of Low Level Light Therapy. Biomudularity Effects of LLLT on Bone Regeneration Absorption Characteristics of Tissues as a Basis for the Optimal Wavelength Choice in Photodermatology Bjordal Meta analyse Acute Pain Bone Repair (3) The effect of 300 mW, 830 nm laser on chronic neck pain: A double-blind, randomized, placebo-controlled study A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders Confounders and magicians Dyson on Mechanisms The importance of coherence in phototherapy Mitochondrial Mechanisms of Photobiomodulation in Context of New Data About Multiple Roles of ATP Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomized placebo or active-treatment controlled trials Photobiomodulation Tissue Effects and Bystanders Lanzafame Editorial Phototherapy Tissue Repair